D-USNIC ACID

PRODUCT IDENTIFICATION
CAS NO. 7562-61-0

D-USNIC ACID
EINECS NO. 231-456-0
FORMULA C18H16O7
MOL WT. 344.32

H.S. CODE

 2932.99.0090

TOXICITY

 Mouse LD50 (Oral):838mg/kg
SYNONYMS (+)-Usnic acid; (+)-Usnein; (+)-Usniacin; Usnea Dasypoga Extract;
D-2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-Dibenzofurandione; (9bR)-2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-(2H,9bH)-dibenzofuran-1,3-dione;

SMILES

 c12[C@@]3(C(Oc1c(c(O)c(c2O)C)C(C)=O)=CC(=O)C(=C3O)C(C) =O)C

CLASSIFICATION

Benzofuran, Polycyclic phenolic compound, Preservative, Cosmetic Ingredient. Biochemical ex Plants

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE yellow crystalline powder
MELTING POINT

201 - 203 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 
FLASH POINT  
STABILITY

Stable under ordinary conditions

GENERAL DESCRIPTION & EXTERNAL LINKS
Usnic acid is extracted from Usnea used as a homeopathic preparation and as a dressing for wounds. Chemically usnic acid is 2,6-Diacetyl-1,2,3,9b-tetrahydro-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione. It is used as an antibacteria agent (antiinfective, antifungal, antitrichomonal) in cosmetics and ointments to prevent skin infection. It is also used in formulating deodorant, mouth-care products.

Product

CAS #
Usnic acid 125-46-2
11024-93-4
17669-01-1
21987-06-4
596-41-8
(-)-Usnic acid 6159-66-6
(+)-Usnic acid 7562-61-0
Usnic acid sodium salt 39012-86-7

Wikipedia Linking:http://en.wikipedia.org/wiki/Usnic_acid

http://ntp.niehs.nih.gov
.....A highly purified form of usnic acid isolated from genus Usnea is commercially available. It is also prepared in tissue culture using tiny segments of thalli from Usnea and Ramalina species. In its purified form, usnic acid has been formulated into creams, toothpaste, mouthwash, deodorants, antibiotic ointments and sunscreen products. Usnea barbata. usnic acid, and copper usnate have been produced as antimicrobial preparations. In Germany, lichen extracts used in cosmetics and pharmaceuticals are marketed under trade names Omnigran a, Granobil, and Usnagren A and T (Reynolds 2000). In Italy, usnic acid has been used in vaginal creams, foot creams, powders, and hair shampoo (Rafanelli et al. 1995). In Argentina, "Barba della Piedra (Usnea densirostra) has been sold to treat many ailments (Correch et al. 1998). In these preparations, usnic acid is employed as an active agent as well as a preservative. The extracts of lichens rich in usnic acid have been utilized in pharmaceuticals, perfumery, cosmetics, and in ecological applications. It has also been indicated that usnic acid could also be used as a biomarker to assess pollution, as its concentration in lichens increases with the increased exposure to toxicants. In recent years, usnic acid containing health food supplements have been promoted as weight reduction products. BIOLOGY:A number of biological roles such as antibiotic, antimycotic, antifeedent, phytotoxic, photobiont regulator, and UV filter etc. have been linked to usnic acid lichens rich in usnic acid. However, it must be mentioned that neither of these effects have been substantiated nor formally attributed to usnic acid......
SALES SPECIFICATION

APPEARANCE

 yellow crystalline powder

ASSAY

 98.0% min
MELTING POINT

201-203 C
OPTICAL ROTATION +470° ~ 505° (C=1, in CHCl3)
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN , Risk Phrases: 22, Safety Phrases: 36